Anti-PspA [2B11], Human IgG1, Fc Silent(tm), lambda

Absolute Antibody

Anti-PspA [2B11], Human IgG1, Fc Silent(tm), lambda

9

This antibody is specific for the Streptococcus pneumoniae PspA. The epitope on PspA was defined to residues 231-242 by mutational analysis and supported by molecular docking analysis.

The dissociation constant (Kd) of the original human scFv version of this antibody was 5.3 +/- 2.3 nM as measured in a biolayer interferometry assay. This antibody detected PspA in immunoblots; it exhibited a dose-dependent recognition of recombinant PspA with no cross-reactivity towards other tested pneumococcal antigens and also detected endogenous PspA from pneumococcal lysates (Jang et al., 2017; PMID: 27845043).

Western Blot, ELISA

Research Use Only

Monoclonal

2B11

Human

IgG1

This is a reformatted human IgG1 Fc Silent Fc Silent™ antibody, based on the original human scFv format, created for improved compatibility with existing reagents, assays and techniques.

Bacteria

-20°C,2°C to 8°C

12352203