Anti-PTEN Rabbit mAb

PTM BIO

Anti-PTEN Rabbit mAb

5

Flow Cytometry, Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P, FC

Research Use Only

Monoclonal

JRMR-10244-3

Unconjugated

Rabbit

IgG

Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dePhosphorylatedrylating tyrosine-, serine- and threonine-Phosphorylatedrylated proteins. Also acts as a lipid phosphatase. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dePhosphorylatedrylating Phosphorylatedinositides and thereby modulating cell cycle progression and cell survival. The unPhosphorylatedrylated form cooperates with AIP1 to suppress AKT1 activation. DePhosphorylatedrylates tyrosine-Phosphorylatedrylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203