Anti-PTPRF/LAR Antibody

HUABIO

Anti-PTPRF/LAR Antibody

7

Flow Cytometry, ImmunoFluorescence, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

IF-Cell,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PTPRF

protein tyrosine phosphatase receptor type F

BNAH2, LAR, receptor-type tyrosine-protein phosphatase F, LCA-homolog, leukocyte antigen-related (LAR) PTP receptor, leukocyte antigen-related tyrosine phosphatase, leukocyte common antigen related, protein tyrosine phosphatase, receptor type, F polypeptide, receptor-linked protein-tyrosine phosphatase LAR

Rabbit

IgG

Receptor-type tyrosine-protein phosphatase F

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Human

Human

-20°C,2°C to 8°C

41116161