Anti-PTPRJ/DEP-1 Mouse mAb

PTM BIO

Anti-PTPRJ/DEP-1 Mouse mAb

5

Flow Cytometry

FC

Research Use Only

Monoclonal

13584

Unconjugated

Mouse

IgG

Receptor-type tyrosine-protein phosphatase eta

Tyrosine phosphatase which dePhosphorylatedrylates or contributes to the dePhosphorylatedrylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dePhosphorylatedrylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dePhosphorylatedrylation. Negative regulator of EGFR signaling pathway; through EGFR dePhosphorylatedrylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dePhosphorylatedrylate PLCG1 and LAT to down-regulate prolongation of signaling.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203