Anti-Pygopus 2 Antibody

HUABIO

Anti-Pygopus 2 Antibody

7

Flow Cytometry, Western Blot

WB,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

PYGO2

pygopus family PHD finger 2

1190004M21Rik, pygopus homolog 2, pygopus 2

Rabbit

IgG

Pygopus homolog 2

Pygopus 2, also known as PYGO2, is a 406 amino acid protein that is the human homolog of the Drosophila pygopus protein. Localized to the nucleus, Pygopus 2 contains one PHD finger that interacts with the homology domain of the Wnt signaling protein Bcl-9. This interaction joins Pygopus 2 with the -catenin/TCF complex (a crucial complex in Wnt signaling), thereby allowing -catenin to transcriptionally activate Wnt target genes. Association of Pygopus 2 with proteins involved in the Wnt signaling pathway is thought to regulate proper signal transduction, as absence of the Pygopus 2/-catenin interaction may play a role in development of B-cell malignancies. In addition, Pygopus 2 expression is upregulated in and required for the growth of breast cancer cells, suggesting a crucial role in carcinogenesis.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161