Anti-RAB8A Antibody [JE64-79]

HUABIO

Anti-RAB8A Antibody [JE64-79]

2

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

JE64-79

1 mg/ml

Unconjugated

RAB8A

RAB8A, member RAS oncogene family

MEL, RAB8, ras-related protein Rab-8A, mel transforming oncogene (RAB8 homolog), mel transforming oncogene (derived from cell line NK14), mel transforming oncogene (derived from cell line NK14)- RAB8 homolog, oncogene c-mel, ras-associated protein RAB8

Rabbit

IgG

Ras-related protein Rab-8A

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.

-20°C,2°C to 8°C

41116161