Anti-RANK-L [14F3]

Absolute Antibody

Anti-RANK-L [14F3]

9

The specificity of the original version of the antibody was confirmed by ELISA analysis (IC50 = 2 nM). The antibody specifically inhibits the functional activity of RANKL induction of DC maturation. The antibody could strongly inhibit the interaction between human RANKL and its receptor RANK in human monocytes. The inhibition led to antagonism of RANKL-mediated DC maturation and osteoclast development and function (US20040213788).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

14F3

TNFSF11

TNF superfamily member 11

CD254, ODF, OPGL, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2, sOdf, tumor necrosis factor ligand superfamily member 11, TNF-related activation-induced cytokine, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa B ligand, tumor necrosis factor (ligand) superfamily, member 11, tumor necrosis factor ligand 6B, tumor necrosis factor superfamily member 11

Mouse

IgG2b

Tumor necrosis factor ligand superfamily member 11

This is a reformatted mouse IgG2b Fc Silent™ antibody, based on the original mouse IgG2a format, created for improved compatibility with existing reagents, assays and techniques.

Human

-20°C,2°C to 8°C

12352203