Anti-RANKL Mouse mAb

PTM BIO

Anti-RANKL Mouse mAb

5

Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry

ICC/IF, FC

Research Use Only

Monoclonal

10476

Unconjugated

Mouse

IgG

Tumor necrosis factor ligand superfamily member 11

Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL has been identified to affect the immune system and control bone regeneration and remodeling. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin (OPG), a ligand for the receptor RANK and controls cell proliferation by modifying protein levels of Id4, Id2 and cyclin D1. RANKL is expressed in several tissues and organs including: skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.

Stable for 12 months from date of receipt/reconstitution.

Human

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203