Anti-Retinoic Acid Receptor alpha Antibody [SN0725]

HUABIO

Anti-Retinoic Acid Receptor alpha Antibody [SN0725]

7

Flow Cytometry, Western Blot

WB,FC

Research Use Only

Monoclonal

SN0725

1 mg/ml

Unconjugated

RARA

retinoic acid receptor alpha

NR1B1, RAR, RARalpha, retinoic acid receptor alpha, PML-DDX5-RARA fusion, PML-DDX5-RARA fusion protein, RAR-alpha, TTMV/RARA fusion, TTMV/RARA fusion protein, nuclear receptor subfamily 1 group B member 1, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form, retinoic acid receptor, alpha polypeptide

Rabbit

IgG

Retinoic acid receptor alpha

Retinoids (RA) are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. RAs activate the retinoic acid receptor (RAR) and retinoid X receptor (RXR) nuclear transcription factor families. Most retinoid forms activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RAR family members, which include RARalpha, RARbeta and RARgamma, have a high affinity for all transretinoic acids and belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. RAR isoforms are expressed in distinct patterns throughout development and in the mature organism. The human RARalpha gene maps to chromosome 17 and is implicated in the chromosomal translocation associated with acute promyelocytic leukemia (APL-M3). Specifically, the RARalpha gene is fused with the promyelocytic leukemia (PML) gene, which encodes the fusion protein PML/RARalpha. The PML/RARalpha fusion protein inhibits PML-dependent apoptotic pathways and halts myeloid differentiation at the promyelocytic stage.

Human

Human

Mouse

-20°C,2°C to 8°C

41116161