Anti-RhoA Antibody [SN0612]

HUABIO

Anti-RhoA Antibody [SN0612]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,FC

Research Use Only

Monoclonal

SN0612

1 mg/ml

Unconjugated

RHOA

ras homolog family member A

ARH12, ARHA, EDFAOB, RHO12, RHOH12, transforming protein RhoA, Aplysia ras-related homolog 12, epididymis secretory sperm binding protein, oncogene RHO H12, small GTP binding protein RhoA

Rabbit

IgG

Transforming protein RhoA

Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of GTPases that in humans is encoded by the RHOA gene. While the effects of RhoA activity are not all well known, it is primarily associated with cytoskeleton regulation, mostly actin stress fibers formation and actomyosin contractility. It acts upon several effectors. Among them, ROCK1 (Rho-associated, coiled-coil containing protein kinase 1) and DIAPH1 (Diaphanous Homologue 1, a.k.a. hDia1, homologue to mDia1 in mouse, diaphanous in Drosophila) are the best described. RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of proteins involved in the regulation and timing of cell division. RhoA is one of the oldest Rho GTPases, with homologues present in the genomes since 1.5 billion years. As a consequence, RhoA is somehow involved in many cellular processes which emerged throughout evolution. RhoA specifically is regarded as a prominent regulatory factor in other functions such as the regulation of cytoskeletal dynamics, transcription, cell cycle progression and cell transformation.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161