Anti-RIP3 Antibody

HUABIO

Anti-RIP3 Antibody

7

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

RIPK3

receptor interacting serine/threonine kinase 3

RIP3, receptor-interacting serine/threonine-protein kinase 3, RIP-3, RIP-like protein kinase 3, receptor interacting protein 3

Rabbit

IgG

Receptor-interacting serine/threonine-protein kinase 3

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161