Anti-RON Antibody [SD2006]

HUABIO

Anti-RON Antibody [SD2006]

7

ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,FC,IP

Research Use Only

Monoclonal

SD2006

1 mg/ml

Unconjugated

MST1R

macrophage stimulating 1 receptor

CD136, CDw136, NPCA3, PTK8, RON, SEA, p185-Ron, macrophage-stimulating protein receptor, MSP receptor, PTK8 protein tyrosine kinase 8, S13 avian erythroblastosis oncogene homolog, S13 erythroblastosis oncogene homolog, c-met-related tyrosine kinase

Rabbit

IgG

Macrophage-stimulating protein receptor

Receptor protein tyrosine kinases (PTKs) have been classified into different subclasses on the basis of sequence similarity and distinct structural characteristics. The c-Met encoded receptor represents the initial member of one class of receptors characterized by a heterodimeric structure and a cysteine-rich extracellular domain. Ron, also designated macrophage-stimulating protein receptor (MSP receptor), p185-Ron, CD136 antigen or PTK8 represents a second member of this receptor class. The intracellular PTK domains of Ron and Met are highly similar (63% sequence identity) while the extracellular domains are less related (25% sequence identity) and both are rich in cysteine residues. Mature Ron receptor is comprised of a disulfide-linked heterodimer formed from an alpha chain (Ron alpha) and a beta chain (Ron beta). Proteolytic processing results in the separation of the N-terminal Ron alpha and C-terminal Ron beta subunits.

Human

Human

-20°C,2°C to 8°C

41116161