Anti-RUVB2 Antibody [A1F1]

HUABIO

Anti-RUVB2 Antibody [A1F1]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Monoclonal

A1F1

2 mg/ml

Unconjugated

RUVBL2

RuvB like AAA ATPase 2

CGI-46, ECP-51, ECP51, INO80J, REPTIN, RVB2, TAP54-beta, TIH2, TIP48, TIP49B, ruvB-like 2, 48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, INO80 complex subunit J, RuvB (E coli homolog)-like 2, TIP60-associated protein 54-beta, erythrocyte cytosolic protein, 51-KD, repressing pontin 52, reptin52 protein

Mouse

IgG2b

RuvB-like 2

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5 to 3) activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes.

Human, Rat

Human,Rat

Mouse

-20°C,2°C to 8°C

41116161