Anti-S100 alpha Antibody [JM51-31]

HUABIO

Anti-S100 alpha Antibody [JM51-31]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IP,IHC-P,FC

Research Use Only

Monoclonal

JM51-31

1 mg/ml

Unconjugated

S100A1

S100 calcium binding protein A1

S100, S100-alpha, S100A, protein S100-A1, S-100 protein alpha chain, S-100 protein subunit alpha, S100 alpha, S100 protein, alpha polypeptide

Rabbit

IgG

Protein S100-A1

The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100 alpha and beta, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin alpha and parvalbumin beta (also designated oncomodulin). The S-100 protein is involved in the regulation of cellular processes such as cell cycle progression and differentiation. Research also indicates that the S-100 protein may function in the activation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly and inhibition of protein kinase C mediated phosphorylation. Two S-100 subunits, sharing 60% sequence identity, have been described as S-100 alpha chain and S-100 beta chain. Three S-100 dimeric forms have been characterized, differing in their subunit composition of either two alpha chains, two beta chains or one alpha and one beta chain. S-100 localizes to the cytoplasm and nuclei of astrocytes, Schwanns cells, ependymomas and astrogliomas. S-100 is also detected in almost all benign naevi, malignant melanocytic tumours and in Langerhans cells in the skin. Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100 alpha and beta are present in a variety of other tissues, and calbindin is present in intestine and kidney.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161