Anti-SAMM50 Antibody [JE61-49]

HUABIO

Anti-SAMM50 Antibody [JE61-49]

2

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE61-49

1 mg/ml

Unconjugated

SAMM50

SAMM50 sorting and assembly machinery component

CGI-51, OMP85, SAM50, TOB55, TRG-3, YNL026W, sorting and assembly machinery component 50 homolog, sorting and assembly machinery 50kDa, transformation-related gene 3 protein

Rabbit

IgG

Sorting and assembly machinery component 50 homolog

Sam50 (sorting assembly machinery component 50 homolog, S. cerevisiae), also known as SAMM50, OMP85, TOB55, TRG-3, CGI-51 or YNL026W, is a beta-barrel multi-pass membrane protein that belongs to the SAM50/omp85 family of proteins. Localizing to the mitochondrion, Sam50 is believed to function in the assembly pathway of mitochondrial outer membrane beta-barrel proteins. More specifically, Sam50 functions as the major component of the SAM (sorting and assembly machinery) complex, also known as the TOB (topogenesis of mitochondrial outer membrane beta-barrel proteins) complex, and is required for cell viability. Exposed to the intermembrane space (IMS), the N-terminal POTRA (polypeptide transport-associated) domain of Sam50 (a domain that is conserved from bacteria to man) functions like a receptor for beta-barrel proteins. The association of the Sam35 subunit of the SAM complex is essential for Sam50 binding to outer membrane substrate proteins.

-20°C,2°C to 8°C

41116161