Anti-SARS-CoV-2 Nucleocapsid Protein Antibody [A4D12]

HUABIO

Anti-SARS-CoV-2 Nucleocapsid Protein Antibody [A4D12]

7

Western Blot, ELISA

ELISA,WB

Research Use Only

Monoclonal

A4D12

2 mg/ml

Unconjugated

N

nucleocapsid phosphoprotein

GU280_gp10, nucleocapsid phosphoprotein

Mouse

IgG1

Nucleoprotein

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

SARS-CoV-2

-20°C,2°C to 8°C

41116161