Anti-SCA-1 Antibody

HUABIO

Anti-SCA-1 Antibody

7

ImmunoFluorescence, Western Blot

WB,IF-Cell

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Ly6a

lymphocyte antigen 6 family member A

Ly-6A.2, Ly-6A/E, Ly-6E.1, Sca-1, Sca1, TAP, lymphocyte antigen 6A-2/6E-1, T-cell-activating protein, lymphocyte antigen 6 complex, locus A, stem cell antigen 1

Rabbit

IgG

Lymphocyte antigen 6A-2/6E-1

Sca-1 stands for Stem cells antigen-1 (official gene symbol: Ly6a). It consist of 18-kDa mouse glycosyl phosphatidylinositol-anchored cell surface protein (GPI-AP) of the LY6 gene family. It is the common biological marker used to identify hematopoitic stem cell (HSC) along with other markers. Sca-1 has a regenerative role in cardiac repair: Host cells with specific Sca-1+CD31- markers arise upon myocardial infarction, with evidence of expression of Sca-1 protein. Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression. Sca-1+ HSCs can be found in the adult bone marrow, fetal liver and mobilized peripheral blood and spleen within the adult animal. An anti-Sca-1 Ab is frequently used in combination with negative selection for expression of a number of cell surface markers characteristic of differentiated cells of hematolymphoid lineages (Lin-) to identify and isolate murine HSCs.

Mouse

-20°C,2°C to 8°C

41116161