Anti-SDHA Antibody [JM10-83]

HUABIO

Anti-SDHA Antibody [JM10-83]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,FC

Research Use Only

Monoclonal

JM10-83

1 mg/ml

Unconjugated

SDHA

succinate dehydrogenase complex flavoprotein subunit A

CMD1GG, FP, MC2DN1, NDAXOA, PGL5, PPGL5, SDH1, SDH2, SDHF, succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial, flavoprotein subunit of complex II, malate dehydrogenase [quinone] flavoprotein subunit, succinate dehydrogenase complex, subunit A, flavoprotein (Fp)

Rabbit

IgG

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

In aerobic respiration reactions, succinate dehydrogenase (SDH) catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol. Four subunits comprise the SDH protein complex: a flavochrome subunit (SDHA), an iron-sulfur protein (SDHB), and two membrane-bound subunits (SDHC and SDHD) anchored to the inner mitochondrial membrane. Mutations to these subunits cause mitochondrial dysfunction, corresponding to several distinct disorders. Mutations in the membrane bound components may cause hereditary paraganglioma, while SDHA mutations are associated with juvenile encephalopathy as well as Leigh Syndrome, a severe neurological disorder. Inactivating mutations in SDHB correlate with inherited, but not necessarily sporadic, cases of pheochromocytoma.

Fish, Human, Mouse

Human,Mouse,Zebrafish

Rat

-20°C,2°C to 8°C

41116161