Anti-SETD1A Rabbit mAb

PTM BIO

Anti-SETD1A Rabbit mAb

5

Flow Cytometry, ImmunoFluorescence, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

IHC-P, ICC/IF, FC

Research Use Only

Monoclonal

JRMR-10325-7

Unconjugated

Rabbit

IgG

Histone-lysine N-methyltransferase SETD1A

hSET1 is a component of the histone methyltransferase (HMT) complex, which is a member of the COMPASS family, has H3K4 methyltransferase activity, and is closely related to development and tumors. hSET1 can produce mono-, di- and Trimethylation at lys4 (K4) on histone H3. This activity is blocked by the pre-methylation of the transcription repressor K9, indicating that the SET1/ASH2 complex can cause crosstalk between K9 methylation and K4 methylation. SET1 protein may play a role in synaptic function and neuron development. In addition, hSET1 protein can affect the proliferation and apoptosis of leukemia cells, and promote differentiation into neutrophils, providing new ideas for the treatment of leukemia and other cancers.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse, Rat

Human, Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203