Anti-SFTSV [40C10], Human IgM, kappa

Absolute Antibody

Anti-SFTSV [40C10], Human IgM, kappa

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This antibody binds a spatial epitope of the severe fever and thrombocytopenic syndrome virus glycoprotein N. This antibody also cross reacts with SFTSV-related Guertu virus (GTV) and Heartland virus (HRTV). Severe Fever with Thrombocytopenia Syndrome (SF

This antibody could recognize SFTSV-infected cells and eukaryotic expression of SFTSV-Gn protein through immunofluorescence assay. This antibody also demonstrates neutralizing activity against SFTS virus of different genotypes and also the SFTSV-related Guertu virus (GTV) and Heartland virus (HRTV) by targeting a spatial epitope of Gn. The IC50 of this antibody against different SFTSV genotypes was HBZN15 (C1, 2.015 ng/mL), WCH (C4, 4.360 ng/mL), HBMC5 (C3, 5.940 ng/mL), HBGS13 (C2, 7.506 ng/mL). The IC50 against HRTV and GTV was 13.12 ng/mL and 8.140 ng/mL, respectively. This antibody also showed therapeutic effect in mice infected with different genotypes of SFTSV strains against death by preventing the development of lesions and by promoting virus clearance in tissues.showed therapeutic effect in mice infected with different genotypes of SFTSV strains against death by preventing the development of lesions and by promoting virus clearance in tissues. The therapeutic effect could still be observed in mice infected with SFTSV which were administered with mAb 40C10 after infection even up to 4 days (PMID: 38848311).

ImmunoFluorescence, Neutralisation/Blocking, Other Application

Research Use Only

Monoclonal

40C10

Human

IgM

Virus

-20°C,2°C to 8°C

12352203