Anti-SFTSV glycoprotein C [SF83], Human IgG1, Fc Silent(tm), kappa

Absolute Antibody

Anti-SFTSV glycoprotein C [SF83], Human IgG1, Fc Silent(tm), kappa

9

This antibody binds the severe fever and thrombocytopenic syndrome virus glycoprotein C. Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease caused by the SFTS virus which is transmitted to humans through the bite of an in

The binding capability of this antibody for SFTSV glycoprotein C was confirmed using ELISA and SPR. This antibody was capable of neutralizing live virus in infected Vero cells with an IC50 of 29.45+/-12.80mg/mL. In an in vivo animal protection experiments the INFAR -/- mice which were injected with a dose of 20 mg/kg of SF83 antibody showed a survival rate of 20%. This antibody in combination with another anti-SFTSV Gn antibody SF5 was used for the generation of a bispecific antibody. In vivo experiments with bispecific antibody increased the survival rates of animals to 100% (CN114736291; PMID:28096333).

ELISA, Neutralisation/Blocking

Research Use Only

Monoclonal

SF83

Human

IgG1

This is a reformatted human IgG1 Fc Silent™ antibody, based on the original human IgG1 format, created for improved compatibility with existing reagents, assays and techniques.

Virus

-20°C,2°C to 8°C

12352203