Anti-Sin1 Mouse mAb

PTM BIO

Anti-Sin1 Mouse mAb

5

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Research Use Only

Monoclonal

JMMR-3344

Unconjugated

Mouse

IgG

Target of rapamycin complex 2 subunit MAPKAP1

Sin1 is the subunit of mTORC2. mTOR is a large protein kinase that is a component of two different complexes. The mTOR complex 1 (mTORC1), a target of rapamycin, contains mTOR, GbètaL, and raptor. mTORC2, insensitive to rapamycin, includes mTOR, GbètaL, Sin1, and rictor. The mTORC2 complex Phosphorylatedrylates Ser473 of Akt/PKB in vitro. This Phosphorylatedrylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 Phosphorylatedrylation in 3T3-L1 adipocytes. mTORC2 has also been shown to Phosphorylatedrylate the rapamycin-resistant mutants of S6K1, another effector of mTOR. In addition, Phosphorylatedrylation of Sin1 at Thr86 by Akt/PKB was shown to regulate the activity of mTORC2 in adipocytes upon stimulation by growth factors.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse

Human, Mouse

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203