Anti-SIRP alpha Antibody [JE36-20]

HUABIO

Anti-SIRP alpha Antibody [JE36-20]

2

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

JE36-20

1 mg/ml

Unconjugated

Sirpa

signal-regulatory protein alpha

Bit, CD172a, Idd13.2, P84, Ptpns1, SHP-1, SHPS-1, SIRP, tyrosine-protein phosphatase non-receptor type substrate 1, CD172 antigen-like family member A, SHP substrate 1, brain Ig-like molecule with tyrosine-based activation motifs, brain immunological-like with tyrosine-based motifs, inhibitory receptor SHPS-1, mSIRP-alpha1, myD-1 antigen, protein tyrosine phosphatase, non-receptor type substrate 1, signal-regulatory protein alpha-1, sirp-alpha-1

Rabbit

IgG

Tyrosine-protein phosphatase non-receptor type substrate 1

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. Binds PTPN11 when tyrosine-phosphorylated, except in macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds FGR. Binds JAK2 irrespective of its phosphorylation status and forms a stable complex. Binds SCAP1 and/or SCAP2. The resulting complex recruits FYB1. Binds PTK2B.

-20°C,2°C to 8°C

41116161