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Western blot analysis of mouse kidney extract using anti-Slc7a8 [Lat2], pAb (AG-25T-0112) at a dilution of 1:800.
Western blot analysis of mouse kidney extract using anti-Slc7a8 [Lat2], pAb (AG-25T-0112) at a dilution of 1:800.
Western blot analysis of mouse kidney extract using anti-Slc7a8 [Lat2], pAb (AG-25T-0112) at a dilution of 1:800.

anti-Slc7a8 [Lat2], pAb

Research Use Only
AG-25T-0120
AdipoGen Life Sciences
ApplicationsWestern Blot, ImmunoHistoChemistry
Product group Antibodies
ReactivityMouse, Rat
TargetSlc7a8
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    anti-Slc7a8 [Lat2], pAb
  • Delivery Days Customer
    10
  • Antibody Specificity
    Recognizes mouse and rat Slc7a8. Detects a ~50kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and other tissues, which is absent in knock-out animals. In some tissues the antibody detects an additional unknown 38kDa band.
  • Applications
    Western Blot, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.5 mg/ml
  • Formulation
    Liquid
  • Gene ID50934
  • Target name
    Slc7a8
  • Target description
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
  • Target synonyms
    AA408822; LA; large neutral amino acids transporter small subunit 2; LAT2; L-type amino acid transporter 2; mLAT2; solute carrier family 7 member 8; solute carrier family 8 (cationic amino acid transporter, y+ system), member 7
  • Host
    Rabbit
  • Scientific Description
    L-type amino acid transporter (LAT) family members are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2) are responsible for the majority of cellular leucine uptake. They show increased expression in many cancers and are critical for control of protein translation and cell growth through the mTORC1 pathway. The increased transporter expression observed in cancers is regulated by transcriptional pathways such as hormone receptors, c-myc and nutrient starvation responses. - Polyclonal Antibody. Recognizes mouse and human Slc7a8. Other species not tested.Detects a ~50kDa Slc7a8 band in wild type mouse brain, kidney, jejunum, ileum and other tissues, which is absent in knock-out animals. In some tissues the antibody detects an additional unknown 38kDa band. Source: Rabbit. Applications: IHC, WB. Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide. L-type amino acid transporter (LAT) family members are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2) are responsible for the majority of cellular leucine uptake. They show increased expression in many cancers and are critical for control of protein translation and cell growth through the mTORC1 pathway. The increased transporter expression observed in cancers is regulated by transcriptional pathways such as hormone receptors, c-myc and nutrient starvation responses.
  • Reactivity
    Mouse, Rat
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203