Anti-Smad5 Antibody [SI17-06]

HUABIO

Anti-Smad5 Antibody [SI17-06]

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Monoclonal

SI17-06

1 mg/ml

Unconjugated

SMAD5

SMAD family member 5

DWFC, JV5-1, MADH5, mothers against decapentaplegic homolog 5, MAD, mothers against decapentaplegic homolog 5, SMA- and MAD-related protein 5, SMAD, mothers against DPP homolog 5, mothers against decapentaplegic, drosophila, homolog of, 5

Rabbit

IgG

Mothers against decapentaplegic homolog 5

Smad proteins, the mammalian homologs of the Drosophila Mothers against dpp (Mad) have been implicated as downstream effectors of TGFbeta/BMP signaling. Smad1 (also designated Madr1 or JV4-1), Smad5 and mammalian Smad8 (also designated Smad9 or MADH6) are effectors of BMP2 and BMP4 function while Smad2 (also designated Madr2 or JV18-1) and Smad3 are involved in TGFbeta and activin-mediated growth modulation. Smad4 (also designated DPC4) has been shown to mediate all of the above activities through interaction with various Smad family members. Smad6 and Smad7 regulate the response to activin/TGFbeta signaling by interfering with TGFbeta-mediated phosphorylation of other Smad family members. Like many other TGFbeta family members SMAD5 is involved in cell signalling and modulates signals of bone morphogenetic proteins (BMPs). The binding of ligands causes the oligomerization and phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFbeta is an inhibitor of hematopoietic progenitor cells.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161