Anti-SOD1 [D3H5], Mouse IgG1, kappa

Absolute Antibody

Anti-SOD1 [D3H5], Mouse IgG1, kappa

9

This antibody was specific for misfolded SOD1 and does not bind to WT SOD1.

The original antibody was used for an ELISA on SOD1 WT and misfolded SOD1. It only showed binding to the misfolded SOD1 protein. This antibody was used for a western blot on SOD1 WT and misfolded SOD1. This antibody was expressed in the spinal cords of mice with a SOD1 mutation simulating ALS. It showed that it delayed disease onset and extended lifespans (Patel et al., 2014; PMID:24394188). This antibody was used for immunohistochemistry on spinal cords from transgenic mice over-expressing the G93A-SOD1 mutation (Gros-Louis et al., 2010; PMID:20345765), and on SOD1G93A rat spinal cords (Pickles et al., 2016; PMID:27121871). The antibody was used for immunoprecipitation on spinal cords from transgenic mice over-expressing the G93A-SOD1 mutation. This antibody was used in vivo on G93A-SO D1 mice. It delayed the mortality on these mice (Gros-Louis et al., 2010; PMID:20345765).

ImmunoPrecipitation, Western Blot, ELISA, ImmunoHistoChemistry, Other Application

Research Use Only

Monoclonal

D3H5

Mouse

IgG1

Human

-20°C,2°C to 8°C

12352203