Anti-Spike protein [Sb23]

Absolute Antibody

Anti-Spike protein [Sb23]

7

Sb23 binds RBD with a very high affinity and neutralizes pseudovirus with an IC50 of 0.6 microg/ml. Sb23 and ACE2 compete for the same or overlapping binding sites on SARS-CoV-2-RBD. ELISA was used to screen the libraries to identify specific RBD binders. It is also reported that since Sb23 can efficiently replace ACE2 from a preformed complex, it has a higher affinity for RBD than ACE2. Biolayer interferometry assay was used to kinetically characterize the interaction of sybodies with RBD and spike (Custodio et al., 2020).

ELISA, Neutralisation/Blocking, Other Application

Research Use Only

This chimeric human antibody was made using the variable domain sequences of the original VHH format, for improved compatibility with existing reagents, assays and techniques.

-20°C,2°C to 8°C

12352203