Anti-SSRP1 Antibody

HUABIO

Anti-SSRP1 Antibody

7

Flow Cytometry, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

SSRP1

structure specific recognition protein 1

FACT, FACT80, T160, FACT complex subunit SSRP1, FACT 80 kDa subunit, FACTp80, chromatin-specific transcription elongation factor 80 kDa subunit, cisplatin-DNA SSRP, facilitates chromatin remodeling 80 kDa subunit, facilitates chromatin transcription complex 80 kDa subunit, facilitates chromatin transcription complex subunit SSRP1, hSSRP1, high mobility group box, recombination signal sequence recognition protein 1

Rabbit

IgG

FACT complex subunit SSRP1

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of Ser-392 of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161