Anti-ST2L [ST2M51], Mouse IgG2b, kappa

Absolute Antibody

Anti-ST2L [ST2M51], Mouse IgG2b, kappa

9

This antibody specifically binds an epitope in domain III of the human ST2L and cross reacts with cynomolgus monkey ST2L. ST2L a transmembrane receptor that belongs to the IL-1 receptor family which is expressed on the cell surface of a wide variety of im

This antibody is not capable of blocking the interaction between IL-33 and ST2L. This antibody was capable of recognizing recombinant human ST2L extracellular domain (ST2L-ECD) using an ELISA assay (PMID: 27294560). The original human IgG2 chimeric version of the antibody binds human and cynomolgus monkey ST2L with a binding affinity of 38 pM and 76 pM respectively (US9090694). This antibody was capable of binding ST2L expressed by LAD2 mast cells in a flow cytometric assay. This antibody was reported to block the IL-33 induced activation of NF-kB in a dose dependent manner. This antibody also blocked IL-1RAcP from binding to the ST2L/IL-33 complex. It can also inhibit cytokine secretion by human basophilic cell line KU812 (PMID: 27294560).

Functional Assay, Flow Cytometry, ELISA

Research Use Only

Monoclonal

ST2M51

IL1RL1

interleukin 1 receptor like 1

DER4; FIT-1; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL33R; interleukin 1 receptor-related protein; interleukin-1 receptor-like 1; ST2; ST2L; ST2V; T1

Mouse

IgG2b

Interleukin-1 receptor-like 1

Human, Monkey

-20°C,2°C to 8°C

12352203