Anti-STAT1 Mouse mAb

PTM BIO

Anti-STAT1 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JMMR-1566

Unconjugated

Mouse

IgG

Signal transducer and activator of transcription 1-alpha/beta

The STAT1 transcription factor is activated in response to a large number of ligands and is essential for responsiveness to IFN-alfa and IFN-gamma. Phosphorylatedrylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding. Stat1 protein exists as a pair of isoforms, Stat1alfa (91 kDa) and the splice variant Stat1bèta (84 kDa). In most cells, both isoforms are activated by IFN-alfa, but only Stat1alfa is activated by IFN-gamma. The inappropriate activation of Stat1 occurs in many tumors. In addition to tyrosine Phosphorylatedrylation, Stat1 is also Phosphorylatedrylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-alfa and other cellular stresses. Serine Phosphorylatedrylation may be required for the maximal induction of Stat1-mediated gene activation.

Stable for 12 months from date of receipt/reconstitution.

Human

Human

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203