Anti-STAT6 (Ab-645)

Applied Biological Materials

Anti-STAT6 (Ab-645)

9

STAT6 (Ab-645) antibody detects endogenous levels of total STAT6 protein.

Western Blot, ImmunoHistoChemistry

Research Use Only

Polyclonal

1 ug/ul

Rabbit

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Human

-20°C,2°C to 8°C

12352203