Anti-Stromal interaction molecule 1 Antibody [SD0814]
ET1612-53
ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetSTIM1
Overview
- SupplierHUABIO
- Product NameAnti-Stromal interaction molecule 1 Antibody [SD0814]
- Delivery Days Customer7
- ApplicationsImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- Applications SupplierWB,IHC-P,IP
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDSD0814
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID6786
- Target nameSTIM1
- Target descriptionstromal interaction molecule 1
- Target synonymsD11S4896E, GOK, IMD10, STRMK, TAM, TAM1, stromal interaction molecule 1
- HostRabbit
- IsotypeIgG
- Protein IDP70302
- Protein NameStromal interaction molecule 1
- Scientific DescriptionCa2+ influx is essential for a variety of cellular functions including, secretion and transcription. Stromal interaction molecule 1 (Stim1) is a ubiquitously expressed cell surface transmembrane glycoprotein that plays a role in medi-ating Ca2+ influx following the depletion of intracellular Ca2+ stores. Stim1 functions in the endoplasmic reticulum (ER) where it acts as a Ca2+ sensor via its EF-hand domain which causes large conformational changes. When Ca2+ levels drop, Stim1 translocates from the ER to the plasma membrane, where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A/Orai1. Stim2 is a potent inhibitor of Stim1-mediated store-operated calcium (SOC) entry. Stim1 is implicated in tumor growth suppression and stromal-hematopoietic cell interactions.
- ReactivityHuman, Mouse, Rat
- Reactivity SupplierHuman,Mouse,Rat
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC41116161