Anti-SUMO-1/2/3 Mouse mAb (N-terminal)

PTM BIO

Anti-SUMO-1/2/3 Mouse mAb (N-terminal)

5

Anti-SUMO-1/2/3 Mouse mAb (N-terminal) detects endogenous levels of SUMO-1/2/3 and SUMOylated proteins.

Western Blot, ImmunoHistoChemistry Paraffin

WB, IHC-P

Antibody

Research Use Only

Monoclonal

Unconjugated

Mouse

IgG

Small ubiquitin-related modifier 1

Small ubiquitin-related modifier 1, 2 and 3 (SUMO-1, 2 and 3) are members of the ubiquitin-like protein family. The functions of the small ubiquitin-related modifier protein is similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. It can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. Ubiquitin predominantly regulates degradation of its target. In contrast, SUMO-1 is conjugated to RanGAP, PML, p53 and IkappaB-alfa to regulate nuclear trafficking, formation of subnuclear structures, transcriptional activity, and protein stability. SUMO-2/3 forms poly-(SUMO) chains, which is conjugated to topoisomerase II and APP, and regulates chromosomal segregation and cellular responses to environmental stress.

Stable for 12 months from date of receipt/reconstitution.

Human, Monkey, Mouse, Rat

Human, Mouse, Rat, Monkey

Protein G and immunogen affinity purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203