Anti-Syntrophin alpha 1 Antibody

HUABIO

Anti-Syntrophin alpha 1 Antibody

7

Western Blot

WB,IF-Cell,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

SNTA1

syntrophin alpha 1

LQT12, SNT1, TACIP1, dJ1187J4.5, alpha-1-syntrophin, 59 kDa dystrophin-associated protein A1 acidic component 1, acidic alpha 1 syntrophin, dystrophin-associated protein A1, 59kDa, acidic component, pro-TGF-alpha cytoplasmic domain-interacting protein 1, syntrophin-1

Rabbit

IgG

Alpha-1-syntrophin

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161