Anti-TAK1 Mouse mAb

PTM BIO

Anti-TAK1 Mouse mAb

5

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry Paraffin

WB, IHC-P, ICC/IF

Research Use Only

Monoclonal

11539

Unconjugated

Mouse

IgG

Mitogen-activated protein kinase kinase kinase 7

Mitogen-activated protein kinase kinase kinase 7 (MAP3K7), also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. TAK1 is a central regulator of cell death and is activated through a diverse set of intra- and extracellular stimuli. TAK1 regulates cell survival not solely through NF-kappaB but also through NF-kappaB-independent pathways such as oxidative stress and receptor-interacting protein kinase 1 (RIPK1) kinase activity-dependent pathway.In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.

Stable for 12 months from date of receipt/reconstitution.

Human, Mouse

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203