Anti TAR DNA-Binding Protein 43 (TDP-43), phospho Ser409 pAb (Rabbit, Antiserum)

Cosmo Bio USA

Anti TAR DNA-Binding Protein 43 (TDP-43), phospho Ser409 pAb (Rabbit, Antiserum)

16

Research Use Only

TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa) and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases. This antibody is a powerful tool for biochemical and immunohistochemical analyses of neurodegenerative diseases and for evaluation of cellular or animal models of TDP-43 proteinopathy. Specifications Product type primary antibody Immunogen CMDSKS(p)SGWGM, S(p): phosphoserine 409 Raised in rabbit Source serum Form liquid antiserum with 0.05% NaN3 as a preservative Volume 100 uL Label unlabeled Specificity phospho-TDP-43 Cross reactivity human Storage below -20°C and below -70°C for prolonged storage; aliquot to avoid freeze/thaw cycles. Recommended dilutions Western blotting 1/1000-1/5000 Immunohistochemistry 1/1000-1/5000 ELISA 1/1000-1/5000 Other applications not tested Optimal dilutions/concentrations should be determined by end user. References <ol> Inukai Y, Nonaka T, Arai T, et al. Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett. 582, 2899-2904, 2008 PubMed: 18656473 </ol>

12352203