Anti-Thioredoxin Antibody [JM10-019]

HUABIO

Anti-Thioredoxin Antibody [JM10-019]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP

Research Use Only

Monoclonal

JM10-019

1 mg/ml

Unconjugated

TXN

thioredoxin

TRDX, TRX, TRX1, TXN1, Trx80, thioredoxin, ADF, ATL-derived factor, SASP, TXN delta 3, surface-associated sulphydryl protein, testicular tissue protein Li 199, thioredoxin delta 3

Rabbit

IgG

Thioredoxin

Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFkB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. TrxR is a ubiquitously expressed flavoprotein that catalyzes the NADPH-dependent reduction of Trx as well as several other oxidized cellular components.

Human

Human

-20°C,2°C to 8°C

41116161