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ProductsBack/anti-Thymidine Glycol [TG], mAb (2E8)

anti-Thymidine Glycol [TG], mAb (2E8)

Research Use Only
JAI-MTG-100P
JaICA
ApplicationsImmunoHistoChemistry
DownloadDatasheet
Product group Antibodies
ReactivityAll Species, Human
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Overview

  • Supplier
    JaICA
  • Product Name
    anti-Thymidine Glycol [TG], mAb (2E8)
  • Delivery Days Customer
    10
  • Antibody Specificity
    Recognizes DNA containing thymidine glycol. Does not cross-react with oxidized dC polymer, oxidized dG polymer and oxidized dA polymer. Does not react with free thymidine glycol.
  • Applications
    ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2E8
  • Formulation
    Liquid
  • Host
    Mouse
  • Isotype
    IgG1
  • Scientific Description
    Monoclonal Antibody. Recognizes DNA containing thymidine glycol. Does not cross-react with oxidized dC polymer, oxidized dG polymer and oxidized dA polymer. Does not react with free thymidine glycol. Lyophilized. Contains 10mM PBS, pH7.4 containing 1.0% BSA. Thymidineglycol (TG) is one of the major oxidation products of DNA. Thymidine (T) can be damaged by oxidative stress such as radiation and energy metabolism. Two different pathways to form TG have been suggested. Deoxythymidine in DNA is directly oxidised by hydroxy radical, to form TG. TG can be also formed through an intermediate thymidine chlorohydrin, which is derived from hypochlorous acid (HOCl) from neutrophil myeloperoxidase. Thymidineglycol is derived from DNA, not from RNA. TG is the oxidative stress marker secific for DNA damage. In comparison with 8-hydroxy-2-deoxyguanosine (8-OHdG), which is the best known DNA oxidation product it was shown that in a lipopolysaccharide (LPS)-treated mouse liver, 8-OHdG can be stained within 24 hours after LPS treatment. TG can be detected within 6 hours, and remains at least for 72 hours. - Thymidineglycol (TG) is one of the major oxidation products of DNA. Thymidine (T) can be damaged by oxidative stress such as radiation and energy metabolism. Two different pathways to form TG have been suggested. Deoxythymidine in DNA is directly oxidised by hydroxy radical, to form TG. TG can be also formed through an intermediate thymidine chlorohydrin, which is derived from hypochlorous acid (HOCl) from neutrophil myeloperoxidase. Thymidineglycol is derived from DNA, not from RNA. TG is the oxidative stress marker secific for DNA damage. In comparison with 8-hydroxy-2-deoxyguanosine (8-OHdG), which is the best known DNA oxidation product it was shown that in a lipopolysaccharide (LPS)-treated mouse liver, 8-OHdG can be stained within 24 hours after LPS treatment. TG can be detected within 6 hours, and remains at least for 72 hours.
  • Reactivity
    All Species, Human
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352203