Anti-Thyroid peroxidase [WR1.7]

Absolute Antibody

Anti-Thyroid peroxidase [WR1.7]

7

The original form of this antibody (human IgG1) binds human TPO with a Kd of 0.29 nM (Chazenbalk et al., 1993; PMID: 7686925). Competition assays revealed that this antibody binds a distinct epitope compared to clone TR1.9 (Chazenbalk et al., 1993; PMID: 7686925). Further competition studies demonstrated that this antibody inhibits TPO autoantibodies in patients sera by interacting with serum TPO autoantibodies (Chazenbalk et al., 1993; PMID: 7505290). Alongside clones TR1.9, SP1.4, and TR1.8, this antibody maps to the immunodominant region of TPO recognized by autoantibodies in patient sera (Nishikawa et al., 1994; PMID: 7512572). This antibody has also been employed in flow cytometry to detect cells expressing surface TPO (Jaume et al., 1999; PMID: 10323395).

Flow Cytometry, Other Application, RadioImmunoAssay

RIA; competition assays; FC

Research Use Only

Monoclonal

WR1.7

TPO

thyroid peroxidase

MSA, TDH2A, TPX, thyroid peroxidase, thyroid microsomal antigen, thyroperoxidase

Human

IgG1

Thyroid peroxidase

-20°C,2°C to 8°C

41116161