Anti-Tim-4 [3A1]

Absolute Antibody

Anti-Tim-4 [3A1]

7

This antibody is specific for murine TIM-4. TIM-4, unlike other TIM family members, is not expressed on T lymphocytes but rather found on antigen-presenting cells such as lymphoid and myeloid dendritic cells and macrophages. TIM-4 has been shown to intera

The original version of this antibody (rat IgG1) specifically bound murine Tim-4 protein, as shown in ELISA and FC assays (Rodriguez-Manzanet et al., 2008; PMID: 18354194). This antibody can block apoptotic body (AB) recognition by CD11b+ peritoneal macrophages and partially inhibit AB uptake by peritoneal B-1 cells (Rodriguez-Manzanet et al., 2010; PMID: 20368430).

Flow Cytometry, ELISA

FC; WB; ELISA; IHC; IF; blocking; therapeutic

Research Use Only

Monoclonal

3A1

Timd4

T cell immunoglobulin and mucin domain containing 4

B430010N18Rik; smuckler; spleen, mucin-containing, knockout of lymphotoxin protein; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin mucin receptor 4; T-cell membrane protein 4; Tim; TIM-; Tim4; TIM-4; TIMD-4

Mouse

IgG1

T-cell immunoglobulin and mucin domain-containing protein 4

This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Mouse

Mouse

This antibody was raised by immunising female Lewis rats (Harlan Sprague-Dawley) with Tim-4:Ig fusion protein in complete Freund's adjuvant.

-20°C,2°C to 8°C

12352203