anti-TIRAP antibody

Arigo Biolaboratories

anti-TIRAP antibody

23

Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Tirap

toll-interleukin 1 receptor (TIR) domain-containing adaptor protein

C130027E04Rik, Mal, Tlr4ap, Wyatt, toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, Toll-like receptor 4 adaptor protein, adaptor protein Wyatt, myD88 adapter-like protein

Rabbit

IgG

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

-20°C

12352203