Anti-TLR4 Mouse mAb

PTM BIO

Anti-TLR4 Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

11485

Unconjugated

Mouse

IgG

Toll-like receptor 4

Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the toll-like receptor family, which belongs to the pattern recognition receptor (PRR) family. Its activation leads to an intracellular signaling pathway NF-kappaB and inflammatory cytokine production which is responsible for activating the innate immune system.It is most well known for recognizing lipopolysaccharide (LPS), a component present in many Gram-negative bacteria (e.g. Neisseria spp.) and selected Gram-positive bacteria. Its ligands also include several viral proteins, polysaccharide, and a variety of endogenous proteins such as low-density lipoprotein, beta-defensins, and heat shock protein.

Stable for 12 months from date of receipt/reconstitution.

Mouse

Protein G purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203