Anti-TNFAIP3 Antibody

HUABIO

Anti-TNFAIP3 Antibody

7

Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P,FC

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

TNFAIP3

TNF alpha induced protein 3

A20, AIFBL1, AISBL, OTUD7C, TNFA1P2, tumor necrosis factor alpha-induced protein 3, OTU domain-containing protein 7C, putative DNA-binding protein A20, tumor necrosis factor inducible protein A20, tumor necrosis factor, alpha induced protein 3, zinc finger protein A20

Rabbit

IgG

Tumor necrosis factor alpha-induced protein 3

A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor kappa B (NFkappaB) gene expression. By inhibiting NFkappaB activation, A20 plays a critical role in terminating NFkappaB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFkappaB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) gamma protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161