Anti-TRADD Antibody

HUABIO

Anti-TRADD Antibody

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IHC-P

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

TRADD

TNFRSF1A associated via death domain

Hs.89862, tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated death domain protein, tumor necrosis factor receptor type 1 associated death domain protein, tumor necrosis factor receptor-1-associated protein

Rabbit

IgG

Tumor necrosis factor receptor type 1-associated DEATH domain protein

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Human, Mouse, Rat

Human,Mouse,Rat

-20°C,2°C to 8°C

41116161