Anti-TRAF2 Antibody [SD205-06]

HUABIO

Anti-TRAF2 Antibody [SD205-06]

7

ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP,FC

Research Use Only

Monoclonal

SD205-06

1 mg/ml

Unconjugated

TRAF2

TNF receptor associated factor 2

MGC:45012, RNF117, TRAP, TRAP3, TNF receptor-associated factor 2, E3 ubiquitin-protein ligase TRAF2, RING-type E3 ubiquitin transferase TRAF2, tumor necrosis factor type 2 receptor associated protein 3

Rabbit

IgG

TNF receptor-associated factor 2

Tumor necrosis factor (TNF)-activated cell signaling is mediated primarily through the TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF-R2. Both TNF receptors are members of the expanding TNF receptor superfamily, which includes the FAS antigen and CD40. Potential insight into an understanding of TNF receptor-mediated signaling was provided by the identification of two related proteins, TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively). Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2. A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40. The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a TRAF-C domain that is necessary and sufficient for CD40 binding and homodimerization.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161