Anti-TRK fused gene Antibody [SD082-0]

HUABIO

Anti-TRK fused gene Antibody [SD082-0]

7

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P,IP

Research Use Only

Monoclonal

SD082-0

1 mg/ml

Unconjugated

TFG

trafficking from ER to golgi regulator

HMSNP, SPG57, TF6, TRKT3, protein TFG, TRK-fused, TRK-fused gene protein, TRKT3 oncogene

Rabbit

IgG

Protein TFG

Oncogenic rearrangements of the NTRK1 gene, which encodes the Trk A protein, are frequently detected in thyroid carcinomas. Such rearrangements fuse the NTRK1 tyrosine kinase domain to 5-end sequences of different genes. TRK-T3 contains 1,412 nucleotides of NTRK1 preceded by 598 nucleotides belonging to TFG (TRK-fused gene), a ubiquitously expressed gene located on chromosome 3. The TRK-T3 protein within the TFG region contains a coiled-coil motif that gives the oncoprotein the capability to form complexes. The cytoplasmic TRK-T3 protein binds to and phosphorylates the Shc and SNT1/FRS2 adaptor proteins, both of which are involved in coupling the receptor tyrosine kinase to the mitogen-activated protein kinase pathway by recruiting Grb2/SOS. SHP-1 also interacts with and down-regulates TRK-T3.

Human, Mouse

Human,Mouse

Rat

-20°C,2°C to 8°C

41116161