Anti-TrkB.T1 [FH1D12]

Absolute Antibody

Anti-TrkB.T1 [FH1D12]

7

This antibody is specific for TrkB.T1 peptide Ac-C(dPEG4)FVLFHKIPLDG. TrkB.T1 is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferati

To validate this antibody, immunohistochemistry was preformed on multi-tissue block containing human brain, mouse brain, TrkB.T1-/- mouse brain, a cell pellet over-expressing TrkB.T1 and a cell pellet without TrkB.T1 were stained using the scFv version of this antibody. Furthermore, the specificity of this antibody was proven using western blot with the mouse version of this clone. Finally, flow cytometry confirmed the specificity of the mouse version of this antibody (Patwell et al, 2020; pmid:32532995).

Flow Cytometry, Western Blot, ImmunoHistoChemistry

IHC; WB; FC

Research Use Only

Monoclonal

FH1D12

NTRK2

neurotrophic receptor tyrosine kinase 2

BDNF/NT-3 growth factors receptor; BDNF-tropomyosine receptor kinase B; DEE58; EIEE58; GP145-TrkB; neurotrophic tyrosine kinase receptor type 2; OBHD; TRKB; trk-B; tropomyosin-related kinase B; tyrosine kinase receptor B

Human

IgG1

BDNF/NT-3 growth factors receptor

This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Human, Mouse

Human, Mouse

This antibody was raised by immunizing male and female 20-week-old C57BL6 mice that were characterized as genetic null for TrkB.T1 with TrkB.T1 peptide Ac-C(dPEG4)FVLFHKIPLDG-OH maleimide coupled to KLH carrier protein.

-20°C,2°C to 8°C

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