Anti-TrkC Mouse mAb

PTM BIO

Anti-TrkC Mouse mAb

5

Western Blot

WB

Research Use Only

Monoclonal

JMMR-2751

Unconjugated

Mouse

IgG

NT-3 growth factor receptor

TrkC, also named as NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autoPhosphorylatedrylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

Stable for 12 months from date of receipt/reconstitution.

Mouse, Rat

Mouse, Rat

Protein A purified

Store at -20°C. Avoid freeze/thaw cycles.

12352203