Anti-Tyrosinase Antibody [JA52-11]

HUABIO

Anti-Tyrosinase Antibody [JA52-11]

7

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

WB,IF-Cell,IF-Tissue,IHC-P

Research Use Only

Monoclonal

JA52-11

1 mg/ml

Unconjugated

TYR

tyrosinase

ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3, tyrosinase, LB24-AB, SK29-AB, monophenol monooxygenase, oculocutaneous albinism IA, tumor rejection antigen AB

Rabbit

IgG

Tyrosinase

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Defects in TYR are the cause of albinism oculocutaneous type 1B (OCA1B) [MIM:606952]; also known as albinism yellow mutant type. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. It is characterized by partial lack of tyrosinase activity.

Human, Mouse

Human,Mouse

-20°C,2°C to 8°C

41116161