Anti-UBA3 Antibody [1B5-2-3-R]

HUABIO

Anti-UBA3 Antibody [1B5-2-3-R]

2

ImmunoFluorescence, Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

1B5-2-3-R

1 mg/ml

Unconjugated

UBA3

ubiquitin like modifier activating enzyme 3

NAE2, UBE1C, hUBA3, NEDD8-activating enzyme E1 catalytic subunit, NEDD8-activating enzyme E1 subunit 2, NEDD8-activating enzyme E1C, Nedd8-activating enzyme hUba3, UBA3, ubiquitin-activating enzyme E1 homolog, ubiquitin-activating enzyme 3, ubiquitin-activating enzyme E1C (UBA3 homolog, yeast), ubiquitin-activating enzyme E1C (homologous to yeast UBA3)

Mouse

IgG1

NEDD8-activating enzyme E1 catalytic subunit

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. This enzyme contains an E2 binding domain, which resembles ubiquitin, and recruits the catalytic core of the E2 enzyme UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.

-20°C,2°C to 8°C

41116161